Targeting transcriptional machinery to inhibit enhancer-driven gene expression in heart failure
نویسندگان
چکیده
منابع مشابه
Targeting the transcriptional machinery with unique artificial transcriptional activators.
The link between a growing number of human diseases and misregulation of gene expression has spurred intense interest in artificial transcriptional activators that could be used to restore controlled expression of affected genes. To expand the repertoire of activation domains available for the construction of artificial transcriptional regulators, a selection strategy was used to identify two u...
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Identical genes in the same cellular environment are sometimes expressed differently. In some cases, including the immunoglobulin heavy chain (IgH) locus, this type of differential gene expression has been related to the absence of a transcriptional enhancer. To gain additional information on the role of the IgH enhancer, we examined expression driven by enhancers that were merely weakened, rat...
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ژورنال
عنوان ژورنال: Heart Failure Reviews
سال: 2019
ISSN: 1382-4147,1573-7322
DOI: 10.1007/s10741-019-09792-3